John Udell's blog says:

I never thought I'd find myself digging around in my Outlook message store, but Mark's SpamBayes addin -- which is written in Python -- turns out to be a great Python/MAPI tutorial. Borrowing heavily from his examples, I came up with a script to extract my Outlook mail to a bunch of files that I could feed to a standalone indexer. [Full story at O'Reilly Network]

This was a fun project that gave me a chance to explore three different technologies: the Lucene search engine, Jython, and Python's MAPI interface. As I learned this morning, my closing lament -- that the CPython/MAPI and Jython/Lucene halves of this project do not communicate directly -- is somewhat mitigated by the existence of Lupy ( 1, 2), a Python port of Lucene. But I think the general point still stands. Must every component be rewritten in every language? Let's not go there. […]

Have a look at Find it indexes your HD, outlook, and let you search the web, it’s very handy and FAST!!!